plasma crp-hs and ferritin concentration related to kidney injury in adult patients with beta-thalassemia: a cross-sectional study in vietnam

Background: kidney injury (ki) is one of the complications of β-thalassemia patients. objectives: to determine the rate of ki and its relationship with plasma ferritin and crp-hs in β-thalassemia patients. methods: a total of 142 patients diagnosed with β-thalassemia (58.5% minor, 17.6% intermedia, and 23.9% major) were included in our study. in all patients, we measured plasma ferritin, crp-hs, urine albumin, and serum creatinine and calculated the urine albumin to creatinine ratio (uacr). based on uacr, we divided the patients into 2 groups: with ki (n = 19, uacr ≥ 3.0 mg/mmol) and without ki (n = 123, uacr < 0.3 mg/mmol). results: the ratio of ki in β-thalassemia patients was 13.4%. the median concentrations of plasma ferritin and crp-hs in the ki group were significantly higher than in the non-ki group (p < 0.001). plasma ferritin and crp-hs were independent risk factors for ki (p < 0.001). at a cut-off value of 2.35 mg/l, plasma crp-hs had a predictive value for ki (auc = 0.841, p < 0.001). similarly, plasma ferritin at the cut-off value of 2394.95 µg/l showed a predictive value for ki (auc = 0.789, p < 0.001). conclusions: the rate of ki was low in adult patients with β-thalassemia. plasma ferritin and crp-hs had a good predictive value for ki in β-thalassemia patients.