Effect of Cool Dialysate on Depression in Patients with Chronic RenalFailure Treated with Hemodialysis: A Randomized Clinical Trial

Ackground: depression is one of the most common psychiatric problems in hemodialysis patients.objectives: this study aimed to evaluate the e ect of cool dialysate on depression in patients with chronic renal failure treated with hemodialysis.methods: this randomized clinical trial was performed on 66 hemodialysis patients su ering from depression. patients were se-lected by a convenience sampling method and divided equally into intervention and control groups randomly by permuted block allocation, each group containing 33 patients. data were acquired with the beck depression inventory-i. the intervention and con-trol groups underwent one month of treatment with cool dialysate at 35.5 and 37°c, respectively. the severity of depression for each group was measured at the end of each treatment stage and two weeks after the intervention. data were analyzed using r version 25 software with a confidence level of 95%.results: there was no statistically significant di erence between the control and intervention groups before and after the interven-tion (p-values more than 0.05). while the mean of depression severity for the control group decreased from 26.15 ± 1.46 to 22.24 ± 2.00 (p-values < 0.01), the mean of depression severity for the intervention group decreased from 25.56 ± 1.28 to 22.41 ± 1.65 by the intervention (p-value > 0.05).conclusions: the application of cool dialysate as a non-pharmacological method did not significantly reduce the severity of de-pression in patients undergoing hemodialysis. therefore, it is advised to perform further studies that include more research units from di erent geographical locations, considering a longer intervening duration.