association between hypoalbuminemia, degree of proteinuria, and lupus nephritis class: a single-center cross-sectional biopsy study

Background: the current study intended to determine whether serum albumin level and urine protein/creatinine rate (upcr) are appropriate predictors of severe lupus nephritis in childhood-onset sle. objectives: following a cross-sectional single-center design, 85 ln children referred to the national children hospital, ha noi, viet nam, from 6/2019 to 6/2020 were recruited. renal biopsy was performed for all participants. methods: following a cross-sectional single-center design, 85 ln children referred to the national children hospital, ha noi, viet nam, from 6/2019 to 6/2020 were recruited. renal biopsy was performed for all participants. results: the mean sledai score of all patients was 14.69. the proportion of patients with high and very high sledai was 61.2 and 17.6%, respectively. themeanconcentration of serumalbuminwas 28.55 g/l,andthe proportion of decreased albumin concentration was 55.3%. the median upcr was 446.6 mg/mmol in which 76.5% of values were 200 mg/mmol. pathological morphology of ln class from i to vi was observed in 0%, 17.6%, 37.6 %, 37.6%, 7.1%, and 0%, respectively. serum albumin level and upcr presented the predictive value for severe and active ln (class iv and v); (auc: 0.725 p < 0.001 for both). conclusions: serum albumin and upcr were appropriate predictors for severe and active ln in vietnamese children.