Vesical Amyloidosis Masquerading as Bladder Cancer with Hematuria

To describe and report a case of an episodic painless hematuria, in a middle aged gentleman whose initial radiological work up and cystoscopic findings suggested localized carcinoma of the urinary bladder. nuclear matrix protein and urine cytology were negative for urotheilal tumor. transurethral resection of bladder wall mass and pathology confirmed amyloidoma (vesical amyloidosis). absence of clinical stigmata of secondary disease and appropriate histopathology confirmed the diagnosis of primary vesical amyloidosis. diagnosis of vesical amyloidosis was based on the awareness of the existence of this entity and the use of appropriate histopathology and surgical resection was performed. we conclude that early diagnosis and prompt resection is necessary for localized vesical amyloidosis presenting primarily with hematuria.