Role of B Cells in Immune Tolerance

B cells are well known for their roles in antibody production, antigen presentation, mod- eling of the spleen architecture, and th1/th2 polarization of t cells. there is increasing evidence that some specific strains of b cells can also act as negative regulators and af- fect the development of graft tolerance. in certain experimental and clinical models, b-cell depletion has produced a time-dependent negative effect on the course of graft tolerance. in this article, we have discussed the implications of recent research on b-cell depletion therapy in transplantation.