Serum leptin in Peritoneal Dialysis: Is It a Useful Biomarker Following Peritonitis?

Implication for health policy/practice/research/medical edu- cation: acute peritoneal dialysis (pd)-associated peritonitis stimulates peritoneal adipocytes to release large amounts of the adiocy- tokine, leptin, into the dialysate and serum. based on recent research, the ensuing acute hyperleptinaemia is transient and may form an important link between chronic inflammation and malnutrition following peritonitis leading to important long-term sequelae for pd patients. future longitudinal clini- cal studies evaluating the impact of acute peritonitis-induced hyperleptinemia on subsequent development of patient-level outcomes, such as malnutrition, inflammation, cardiovascu- lar events, and technique and overall survival, are warranted.