Effect of Vitamin E Supplementation on Plasma Lipid,Apolipoprotein and Lipoprotein Profiles in Patients on PeritonealDialysis and Hemodialysis

Background and aims: dyslipidemia is one of the well known risk factor for cardiovascular disease in patientson dialysis. the aim of the present study was to assess the influence of vitamin e therapy on lipid profile inpatients on hemodialysis (hd) and peritoneal dialysis (pd).methods: this was a case-control study. the study was performed on 34 hd patients, 13 pd patients and22 healthy volunteers with a mean age of 45.57 ± 8.54 years. hd patients were divided into two groups, i.e.treatment (n=19) and control (n=15). vitamin e was administered, 300 mg/day, to the hd treatment groupand pd patients for 20 weeks. plasma total cholesterol, triglyceride, high-density lipoprotein cholesterol, lowdensitylipoprotein cholesterol, very-low density lipoprotein cholesterol, apolipoprotein a-i, apolipoprotein b,and lipoprotein(a) were examined before and after vitamin e treatment.results: before vitamin e treatment, the levels of high-density lipoprotein cholesterol were significantly lowerin the hd patient group (35.91±10.54 mg/dl) and pd group (37.92±7.19 mg/dl) than the healthy group(44.27±8.33 mg/dl), (p=0.008). before the treatment the levels of lipoprotein(a) were significantly higher in thehd group (28.12±10.85 mg/dl) and pd group (31.64±15.12 mg/dl) than the healthy group (22.09±9.05 mg/dl), (p=0.008). lipid and lipoprotein levels in hd and pd groups were not changed significantly after vitamine treatment.conclusions: vitamin e supplementation is not effective on lipid and lipoprotein levels in patients on hd andpd.