Hypertension in Autosomal Dominant Polycystic KidneyDisease: A Clinical and Basic Science Perspective

Background and aims: cardiovascular complications are major causes of morbidity and mortality inpatients with autosomal dominant polycystic kidney disease (adpkd). in particular, hypertensionis insidious and remains a continuous problem that evolves during the course of the disease. hypertensionin adpkd has been associated with abnormality in the renin-angiotensin-aldosteronesystem (raas). early vascular changes have also been reported in young adpkd patients. inaddition, the cellular functions of mechanosensory cilia within vascular system have emergedrecently. the basic and clinical perspectives of raas, vascular remodeling and sensory cilia arereviewed with regard to hypertension in adpkd.