evaluation of ykl-40 serum level in patients with type 1 diabetes and its correlation with their metabolic and renal conditions

Background: the main indicator of long-term glycemic control in type 1 diabetes and its complications is glycosylated hemoglobin (hba1c). considering that there are little studies on the correlation of ykl-40 with hba1c in type 1 diabetes, we evaluated such correlation to suggest ykl-40 as both diagnostic and prognostic marker of type 1 diabetes poor control and nephropathy. methods: 49 patients of type 1 diabetes not suffering from any diabetic complications during recent 5 years and 43 sex- and agematched healthy controls participated in the study. taking fasting blood and urine samples, we measured cbc, serum levels of ykl-40, hba1c, creatinine, lipids, and urinary concentration of albumin and creatinine using standard laboratory methods. results: serum level of ykl-40 was significantly higher in type 1 diabetes compared to controls (p < 0.001). there was no significant correlation between such levels and hba1c (p = 0.99) in type 1 diabetic patients. there was a strong positive correlation between ykl-40 and duration of the disease (p < 0.001).we found no significant correlation between serum level of ykl-40 and other factors including urine/albumin creatinine ratio (uacr), blood pressure, lipid profile, and serum and urine creatinine. conclusions: although there was a significant increase in serum level of ykl-40 in type 1 diabetic patients, it did not show any correlation with both metabolic and nephropathic states of diabetes.