systemic inflammation and seminal parameters in chronic hemodialysis patients

Objectives]we proposed to investigate the possible effect and association of systemic inflammation (si) and seminal parameter indicators in chronic hemodialysis patients.[methods]this was a crosssectional study. all the participants were subjected to a spermiogram with calculation of fertility index (fi), serum creactive protein (crp) level, seminal transferrin (st) level, as well as evaluation of the hormonal profile (hp). the sample consisting of 60 men (cases) undergoing hemodialysis for more than 6 months was subdivided into 3 groups: group 1 (n = 30, with inflammation, crp gt; 5 mg/l), group 2 (n = 30, without inflammation, crp ≤ 5 mg/l), and group 3 (n = 30, healthy men, crp ≤ 1).[results]age was similar in the 3 groups (p = 0.43). fi, testosterone total and st levels were significantly lower in the case groups than in the control group (p lt; 0.001). follicle stimulating hormone, luteinizing hormone, and prolactin levels were significantly higher in the case groups than in the control group (p lt; 0.001). between the subgroups of cases (groups 1 and 2), the inflammatory factor alone does not seem to interfere with the fi, hp, and st level (p gt; 0.05). however, it significantly interfered with the fi, hp, and st level when compared between the case groups and the control group (p lt; 0.001). no correlation was observed between si and analyzed parameters (p gt; 0.05).[conclusions]the results suggest that the si alone has no effect and is not associated with the fi or st level in a patient undergoing chronic hemodialysis.