Letter to Editor: New Feature of Tuberous Sclerosis or Acute Periventricular Leukomalacia?

We read with interest the article by langer et al., describing the mri findings in a neonatal patient with tuberous sclerosis. they describe the presence of periventricular white matter lesions in the centrum semiovale, with linear, circular, and semicircular shapes, with hyperintense margins, and isointense centers, and better seen on t1-weighted and t1 flair sequences than on t2-weighted sequences. they propose that these target-like lesions have not been previously reported in patients with tuberous sclerosis.we believe that what langer et al. are showing is unrelated to tuberous sclerosis itself, and represents additional classical mri findings of acute periventricular leukomalacia and acute white matter injury.