immunoglobulin g4-related disease unilaterally involving the pulmonary interstitium and pleura: a case report

Immunoglobulin g4-related disease is a novel inflammatory entity involving multiple organs of the body. in the lungs, it is accompanied by infiltration of igg4-positive lymphocytes and increased serum levels of igg4. previous studies have reported radiological findings of igg4-related lung disease in the pulmonary parenchyma; however, there are few case reports of pleural involvement. here, we report the case of a 66-year-old man with igg4-related disease unilaterally involving the lung interstitium and pleura. thoracic computed tomography images demonstrated pleural effusion and thickening resembling a primary or secondary pleural malignancy. the diagnosis of igg4-related disease was confirmed by video-assisted-thoracoscopic biopsy. this rare disease should not be overlooked in patients with radiological findings that are suggestive of pleural malignancies.