effect of periodontal treatment on the crevicular level of highmobility group box 1 and soluble triggering receptor expressed on myeloid cells 1 in patients with chronic periodontitis

The present study aimed to compare the levels of high-mobility group box 1(hmgb1) and soluble triggering receptor expressed on myeloid cells (strem1) in the gingival crevicular fluid (gcf). this cross-sectional cohort trial investigated two groups of 22 eligible chronic periodontitis and 22 periodontally healthy individuals (student volunteers) both before and after the periodontal treatment. gcf was collected from the deepest pockets with clinical attachment loss≥3 mm. both groups received oral hygiene instructions, and scaling and root planning were performed in the test group. enzyme-linked immunosorbent assay kit (elisa) was used to measure the levels of hmgb1 and strem1 in gcf samples collected before and 1 month after non-surgical periodontal treatment. the results showed that hmgb1 levels were significantly higher in the chronic periodontitis patients than those of the healthy individuals before treatment (p<0.02) and decreased significantly after periodontal treatment, which reduced gingival inflammation. furthermore, the levels of strem1 marker were significantly higher in periodontitis patients before (p<0.001) and 1 month after treatment than in healthy individuals (p<0.003) although its crevicular levels decreased after periodontal therapy in periodontitis group. the higher levels of strem1 and hmgb1 cytokines in gcf of periodontitis patients and the significant decrease after the introduction of the periodontal treatment underlines the importance of hmgb1 and strem1 in pathogenesis of periodontitis.