Intravenous Immunoglobulin in the Treatment of Lamotrigine- Induced Toxic Epidermal Necrolysis

Toxic epidermal necrolysis is a potentially life-threatening disease, which needs necessarytreatment.we present a 12 years old female who was a known case of idiopathic generalized tonicclonicconvulsion and presented with fever, diarrhea and generalized erythematous eruptionafter 2 weeks of being under treatment with maintenance doses of lamotrigine (ltg) andvalproate (vpa). the eruption led to more than 90% epidermal detachment of the totalbody surface area. however, she made a full recovery with few negligible sequelae regardingthe severity of her disease and the symptomatic therapy and intravenous immunoglobulin(ivig) administration which started soon after the bullae appeared.while ivig might be beneficial in the treatment of ten, controlled studies are neededto evaluate the efficiency of ivig compared to other modalities.