Association of HLA class II Alleles with Childhood Asthma and Total IgE Levels

Asthma is a complex and multifactorial disorder. several studies have reported associationbetween different hla- dqb1 and hla- drb1 alleles and allergic asthma. the aim ofthe present study was to investigate the association of hla-class ii alleles and haplotypes,with total serum ige and the results of the skin prick test in iranian children with allergicasthma.a total of 112 patients with allergic asthma symptoms (75 males and 37 females) were selectedrandomly from the pediatric hospital. in some patients total serum ige and prick testwere determined.data of this study shows that hla-drb1*12 significantly increased in asthmatic patients(4.5% vs. 0%, p-value=0.04). hla-dqb1*0603 and 0604 alleles were significantly higher inasthmatics than those in normal controls (10% vs. 0%, p-value= 0.0001; and 9.3% vs. 3.7%,p-value= 0.04, respectively). the statistical significance was relinquished after p value correctionfor all alleles except for hla-dqb1*0602 (pc=0.03) and hla-dqb1*0603(pc=0.0015). conversely, hla-dqb1*0501 and 0602 were decreased in asthmatics comparedto normal controls (7.5% vs. 13.5%, p-value= 0.05; and 4% vs. 12.5%, p-value= 0.002,respectively). the mean of total ige in patients was 483 iu, and it was significantly highabout 1140 iu in asthmatic patients with positive skin prick test to house dust. the most frequentalleles in asthmatic patients with the total ige>200 iu/ml were hla-drb1*11and1401, hla-dqa1*0505, hla-dqb1*0301 and in patients with total ige<200 iu/mlwere hla-drb1*0301, 07 and 1301, hladqa1*0201 and 0301, hla-dqb1*0201.these data suggests that hla-drb1, dqa1 & dqb1 alleles and haplotypes might beimplicated in susceptibility to allergy and asthma and serum ige production. as asthma andatopy are multifactorial disorders, probably hla genes are involved in the regulation of immunespecific responses to common allergen.