Presence of Idiopathic Thrombocytopenic Purpura and Autoimmune Hemolytic Anemia in the Patients with Common Variable Immunodeficiency

Common variable immunodeficiency (cvid) is a heterogeneous group of disorderscharacterized by hypogammaglobulinemia and an increased susceptibility to recurrentinfections as well as autoimmunity and malignancies. idiopathic thrombocytopenic purpura(itp) and autoimmune hemolytic anemia (aiha) are two autoimmune disorders whichmay be seen in association with cvid.among 85 cvid patients, seven cases had itp and/or aiha (8%). four of thesepatients had one or more episodes of itp, one patient had aiha, and two patients had bothitp and aiha (evans syndrome).almost, all patients experienced chronic and recurrent infections mostly in respiratoryand gastrointestinal systems during the course of the disease. among the seven patients, fivepresented their underlying disease with recurrent respiratory and/or gastrointestinal tractinfections, while in two remaining patients, cvid was presented with itp. three patientsdied until now; two because of hepatic failure and one due to pulmonary hemorrhage.as cvid is prone to autoimmune disorders, it should be considered as a differentialdiagnosis of adult-onset itp and possibly in children. chronic and recurrent itp, especiallyin the presence of propensity to respiratory and gastrointestinal infections mandate theevaluation for an underlying immune dysregulation such as cvid.