Selective Immunoglobulin A Deficiency in Iranian Blood Donors: Prevalence, Laboratory and Clinical Findings

Selective deficiency of immunoglobulin a (iga) is the most frequent primaryhypogammaglobulinemia. as some iga-deficient patients have iga antibodies in theirplasma which may cause anaphylactic reactions, blood centers usually maintain a list of igadeficientblood donors to prepare compatible blood components.in this study we determined the incidence of selective iga deficiency (sigad) in normaladult iranian population. 13022 normal iranian blood donors were included in this study. theassay which we used was adapted to the manual pipetting system and elisa reader was usedfor screening. other classes of immunoglobulins (g, m), as well as secretory iga and iggsubclasses were tested in iga deficient cases by elisa. spss was used for statistical analysis.among 13022 studied cases, 11608 blood donors were males (89.14%) and 1414 werefemales (10.86%). their mean (±sd) age and weight were 38.5±11 years and 82±12 kgrespectively. twenty of the screened samples were found by means of elisa to be igadeficient(less than 5mg/dl), (frequency; 1:651). the data could indicate a compensation foriga deficiency by serum igm in one of our iga deficient cases (patient 5). we observed acorrelation between igg3 and serum iga in deficient cases (r=0.498, p=0.025). our resultsindicate that in present study the prevalence of s iga d is in agreement with data from othercaucasians populations (from 1:300 to 1:700).in conclusion, selective iga deficiency could be almost asymptomatic in most cases ingeneral population. our study suggests that; due to high frequency of iga deficiency in iran,it seems necessary to measure iga levels for every blood donor and blood recipient to findiga deficient cases.