Association of Cytokine Gene Polymorphisms with Bronchial Asthma in Macedonians

Bronchial asthma is a multifactorial disease whereby both environmental and geneticfactors contribute to its aetiology and/or clinical severity. the aim of this study was toexamine the association of 22 cytokine gene polymorphism in the macedonian populationwith bronchial asthma (ba).the sample of the population comprised of 301 normal unrelated individuals and 74patients with ba. cytokine genotyping was performed by pcr.susceptible cytokine polymorphisms for ba for ten genotypes (il-4 -1098/t:t, tnf- alpha-238/a:g, il-4 -590/c:c, il-2 +166/t:t, il-2 -330/t:t, il-10 -1082/g:g, ifn gammautr5644/t:t, il-10 -1082/a:a, il-1beta +3962/t:t, il-6 -174/g:g), six diplotypes, fourhaplotypes, and two alleles were found. protective cytokine polymorphisms for ba for sevencytokine genotypes (il-4 -1098/g:t, tnf- alpha/g:g, il-2 -330/g:t, il-4 -590/c:t,ifn gamma utr5644/a:t, il-1beta +3962/c:t, il-10 -1082/a:g), six cytokine diplotypes, fourcytokine haplotypes, and four cytokine alleles were found.we concluded that several cytokine polymorphisms are protective, or susceptibleassociated with ba in population of macedonians.