Purified Aged Garlic Extract Modulates Allergic Airway Inflammation in Balb/c Mice

Garlic is known as a potent spice and a medicinal herb with broad therapeutic propertiesranging from antibacterial to anticancer and anticoagulant. our previous studies have shownsome immunoregulatory effects for aged garlic extract, suggesting a key role for 14-kdglycoprotein of garlic in shifting the cytokine pattern to t helper-1.in present study, we investigated the effect of 1, 2, and 3 times intraperitoneal injectionsof aged garlic extract on an established allergic airway inflammation in murine model(balb/c mice). the garlic extract, isolated by biochemical method, includes proteinsprecipitation by ammonium sulfate. after injection of the aged garlic extract, ifn-gamma, antiallergen specific ige and igg1 were measured in lavage and serum by elisa and histologicalassessment was performed on the lung tissues.the results indicated that three-time intra peritoneal injections of the aged garlic extractcaused a significant decrease in the hallmark criteria of allergic airway inflammation levelswhich included eosinophil percentage in lavage, peribronchial lung eosinophils, igg1 level inlavage and serum, mucous producing goblet cells grade and peribronchial and perivascularinflammation.our findings in the present research suggested that aged garlic extract has the potential ofattenuation of inflammatory features of allergic airway inflammation in murine model.