association between ptpn22/ctla-4 gene polymorphism and allergic rhinitis with asthma in children

Allergic rhinitis (ar) is an ige-mediated upper airway disease, and its impact on asthma has been widely recognized. protein tyrosine phosphatase non-receptor 22 (ptpn22) gene and the cytotoxic t-lymphocyte–associated antigen 4 (ctla-4) gene polymorphisms have been reported to be associated with several immune-related diseases. here we investigated the reffect of these two genes’ polymorphisms on the risk of ar and asthma in chinese han children. a total of 106 ar patients, 112 ar with asthma patients, and 109 healthy children were enrolled in the study. the snps of ptpn22 (rs2488457, rs1310182, rs3789604) and ctla-4 (rs3087243, rs11571302, rs11571315, rs231725, rs335219727, and rs4553808) were genotyped using a pcr-restriction fragment length polymorphism assay. for ptpn22, an increased prevalence of the cc genotype and c allele in rs1310182 were identified in ar group. for ctla-4, aa genotype and a allele in rs3087243 and rs231725 were increased in ar with asthma group while in ar group, aa genotype and a allele in rs231725 were obviously decreased. this study reveals a significant association between snps in ptpn22, ctla-4 gene and ar with asthma in chinese han children, which might be susceptibility factors for ar and asthma.