Desmoglein Elisa in the Diagnosis of Pemphigus and Its Correlation With the Severity of Pemphigus Vulgaris

Anti-desmoglein 3 and 1 autoantibodies are involved in the pathogenesis of pemphigusdiseases. our objective was to assess the value of elisa in the diagnosis of pemphigus andits correlation with the severity of pemphigus vulgaris.based on clinical presentation and histopathologic confirmation for the diagnosis of thepemphigus, 38 patients took part in the study. sera of the patients were tested by desmoglein1 and desmoglein 3 elisa. also, direct immunofluorescence was performed for all patientswhich revealed positive results in 36 patients (94.7%).elisa was positive in 37 of 38 pemphigus patients (sensitivity: 97.3%). the relationship betweendesmoglein 1 index values and skin severity was statistically significant (p<0.05). desmoglein3 index values increased with oral severity although this was not statistically significant. iranianpatients similar to indian patients had higher positive anti-desmoglein 1 autoantibodies.desmoglein-elisa test is appropriate in the diagnosis of pemphigus. desmoglein 1 indexvalue is statistically correlated with the severity of pemphigus vulgaris.