Association of Cytokine Gene Polymorphisms With Chronic Obstructive Pulmonary Disease in Macedonians

The aim of this study was to examine the association of 22 cytokine gene polymorphismin macedonians with chronic obstructive pulmonary disease (copd).the sample of the population comprised of 301 normal respondents and 62 patients withcopd. cytokine genotyping was performed by polymerase chain reaction with sequencespecificpriming (pcr-ssp).positive (susceptible) association was found between patient with copd and il-1α -889/c allele; where as negative (protective) association among was found for the followingalleles il-1β +3962/c; il-12b -1188/a; ifnγ +874/t; il-2 -330/g; il-4 -1098/g and il-4-33/c. we found positive (susceptible) association between patients with copd and followinggenotypes: il4 -33/t:t; ifnγ +874/a:a; il-4 -1098/t:t ; il-1α -889/c:c; il-1β+3962/c:t; il-12b -1188/c:c; il-4rα +1902/g:g; il-10 -1082/g:g; il-2 -330/t:t; il-4-590/c:c; and il-1α -889/c:t. negative (protective) association between patients withcopd and following genotypes was found: ifnγ +874/a:t; il-4 -33/c:t; il-4 -1098/g:t;il-2 -330/g:t; il-1β +3962/c:t; il-4 -590/c:t; il-10 -1082/a:g; and il-4 -33/c:c. positive(susceptible) association between patients with copd and following haplotypes wasfound: il-4/tct; il-10/atc; and il-2/tg, and negative (protective) association wasfound between the patients with copd and haplotypes for: il-4/ttc; and il-4/gcc.it could be concluded that several cytokine polymorphisms are positively (susceptible), ornegatively (protective) associated with copd in macedonians.