Disseminated Mycobacterium bovis Infection after BeG Vaccination

The calmette-giierin vaccine (bcg) is administered to all the newborns in iran in orderto prevent tuberculosis. complications of this vaccine are uncommon. ve reportdisseminated bcg disease in 17 patients less than 10 years old.this is a retrospective study of total of 17 cases who were admitted in children medicalcenter hospital with systemic syndrome compatible with mycobacterium disease withevidence of histopathologic demonstration of acid-fast bacilli during 1995-2004.fourteen cases occurred in children younger than 1 year old. nine patients were female.ten of the 17 total cases were associated with an immune deficiency including severecombined immunodeficiency, chronic granulomatous disease and cell mediated immunedefect. response to therapy was ineffective and 10 of them (58.8%) died.disseminated bcg disease is an uncommon but devastating complication of vaccinationthat should be considered in the appropriate clinical setting. immune-compromised infantsare at greatest risk and they respond poorly to standard therapies.