Association between the Polymorphism of TGF-(BETA)1 Gene Promoter (-509C(GREATER THAN)T) and Idiopathic Chronic Urticaria

Idiopathic chronic urticaria (icu), the most common form (70-80%) of chronic urticariais supposed to have immune basis causes. it is speculated that the promoter polymorphismoftgf-(beta)1 gene may be involved in icu. this condition is thought to affect at least 0.[0;0 ofthe population and often can be severe and difficult to treat.a total of 40 patients with leu and 41 normal subjects were studied. dna was extractedfrom whole blood and tgf-(beta)1 promoter -509c(greater than)t polymorphism was determined by pcrrflpmethod.out of the 40 patients with icu, 11 (27.5%) had cc, 2() (65%) had ct and 3 (7.5%)) hadtt genotypes, a higher proportion of case subjects with the c allele (ct type or cc type)was found compared with the t allele.these results do suggest an influence of gcnetic variability at the promoter of tgf-(beta)1gene (-509c(greater than)t) on the occurrence of icu. this polymorphism has been shown as a usefulgcnetic change in our study. furthcr work is required to confirm this result,