Dendritic Cells Bearing HLA-G Inhibit T-Cell Activation in Type 1 Diabetes

Hla-g is normally expressed o n hum an troph oblast cells. it is a no n-class ical mhcmolecule class i b. th e role o f hla -g in diab etic type 1 is not known.we investigated th e role o f ifn-(beta) in induction hla-g expression o n th e monocytederived dendritic cells (dc) in diabetes type 1.t reatm ent of dendritic cell with ifn-(beta) in vitro from diabetic patients (n=20) and normalsubjects (n=20) resulted to the production and exp ression of hla-g o n th ese cells from bothgrou ps. however, comparison of dc from the diabetic patients with dc from the co ntrolsrevealed lower levels o f hla-g molecul es in dc from diabetic patients. using mixedlymphocyte reaction (mlr), it was found th at dc exp ressing f-1la-g mediated the inhibitionof auto logo us t cell activatio n.it is co ncluded that i fn - (beta) can increase hlj-g in dc from diabetic pati ents; subse quentlyit may prevent the immune regularly pathway in th e diabetic pathogenesi s