Systemic and Local Reactions of Bee Venom Immunotherapy in Iran

Severe allergic reactions during specific immunotherapy may occur in the treatment ofhymenoptera sting allergy. the objective of the present study was to examine thecharacteristics of allergic reactions during specific immunotherapy in patients with allergytowards hymenoptera venom in the iranian population.a prospective study was performed using the clinical reports of 27 patients withanaphylaxis to bee venom (apis melifera, geupes vespula and geupes polites). ten patientstreated with cluster protocol during 2002 and 2006after diagnosis of hymenoptera sting allergy according to history and intradermal tests,the patient were treated with cluster protocol immunotherapy. the protocol lasted 6 weekswith an increase in the concentration of venom from 0.01 [j. g/ml to 100 [j. g / ml. none ofthe patient received premedication. all patients with hymenoptera venom allergy received120 injections. anaphylactic reactions were classified according to the mueller-classification.the frequencies of systemic reactions during cluster protocol were 8.33% and 5% foryellow jacket and honey bee venom respectively. no patient experienced severe systemicreaction.cluster protocol for hymenoptera immunotherapy is a reliable method for the treatmentof anaphylactic reactions to bee venom, it is safe with low cost and do not needhospitalization.