Recurrent Infections and Bilateral Uveitis in a Patient with CD8 Deficiency

Cds deficiency is a rare primary immunodeficiency with low or absent peripheralcds cells which results from tap deficiency, zap 70 deficiency and cds a genemutation.we report a 14 year old female who presented with a history of recurrentpneumonia, bronchiectasis, otitis, severe varicella, herpetic lesions of mouth, bilateraluveitis, and cataract formation since the age of s years.she had growth failure, a huge spleen and moderate clubbing. in immunologicworkup, humoral and phagocytic systems were normal. dth response to candida, ppdand dt were negative but ltt response to pha mitogen was normal. hla typingshowed normal class i expression. flowcytometry of peripheral blood showed cds: 0to 2% (absolute count, 0-60 cells/mrrr') with increased cd4/cds ratio on severaloccasions.diagnosis of this patient cannot be hla class r deficiency (tap 1 or tap2),because class i expression had been normal. it is possible to be zap -70 deficiency orcds a gene mutation. bilateral uveitis in our patient was a unique presentation whichmight have resulted because of immune dysregulation in cid.