Nerve Growth Factor Prevents Demyelination, Cell Death and Progression of the Disease in Experimental Allergic Encephalomyelitis

Experimental allergic encephalomyelitis (eae), a demyelinating disease induced in theanimals parallels multiple sclerosis in human in several aspects, provides a useful model toinvestigate multiple sclerosis,in this study, we have therefore used this model to study functions of nerve growthfactor (ngf) in eae. ngf with considerable effects on neuron survival, proliferation anddifferentiation of the nervous system, is also known to act on cells of the immune system.simultaneous up regulation of proinflammatory cytokines and increased level of ngf pointsat possible effects of the nerve growth factor in autoimmune diseases.to investigate roles of ngf in experimental allergic encephalomyelitis in 7)/7)0, wetherefore decided to apply it intracerebroventricularly at a dose of 0.20 mg/mice prior to theinduction of eae.our clinical observations showed that in the eae induced animals who received ngf,severity of the disease was reduced significantly compared to that in saline treated eae mice.also neuropathological investigation of spinal cords revealed that in contrast to saline treatedear mice, no signs of cell death, infiltration and demyelination can be seen in ngf treatedear mice, suggesting that ngf may have clinical implications in multiple sclerosis.