Association between peptidylarginine deiminase type 4 rs1748033 polymorphism and susceptibility to rheumatoid arthritis in Zahedan,Southeast Iran

There are controversial reports regarding the role of peptidylarginine deiminase type 4 (padi4) gene polymorphisms and risk of rheumatoid arthritis (ra). the aim of the present study was to investigate the impact of padi4 rs1748033 polymorphism and susceptibility to ra in a sample of the iranian population. this case-control study was done on 150 patients with ra and 150 healthy subjects. padi4 rs1748033 genotyping was done using amplification refractory mutation system-polymerase chain reaction (arms-pcr) assay. the padi4 rs1748033 variant increased the risk of ra in codominant (or=1.67,95%ci=1.03-2.71,p=0.048,ct vs cc; or=2.73,95%ci=1.25-5.97,p=0.013,tt vs cc) and dominant (or=1.84,95%ci=1.15-2.92,p=0.014,ct+tt vs cc) tested inheritance models. in addition,the padi4 rs1748033 t allele increased the risk of ra (or=1.63,95%ci=1.16-2.29,p=0.006) in comparison with c allele. in conclusion,our finding indicated that padi4 rs1748033 gene polymorphism increased the risk of ra in a sample of the iranian population. copyright © spring 2015,iran j allergy asthma immunol. all rights reserved.