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Association of HLA-DRB1 alleles with ulcerative colitis in the city of Kerman,South Eastern Iran
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نویسنده
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mohammadi m. ,rastin m. ,rafatpanah h. ,sereshki h.a. ,zahedi m.j. ,nikpoor a.r. ,baneshi m.r. ,hayatbakhsh m.m.
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منبع
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iranian journal of allergy, asthma and immunology - 2015 - دوره : 14 - شماره : 3 - صفحه:306 -312
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چکیده
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The association of hla class ii genes with ulcerative colitis (uc) as an autoimmune disease has been investigated for several years. however,factors responsible for genetic predisposition of this disease have so far not been clearly understood. in this study,for the first time,we aimed to investigate the association between hla-drb1 types and uc in the population of kerman,a city southeast iran. hla typing was performed among 85 uc patients and 95 healthy controls using pcr amplification,employing sequence specific primers (pcr-ssp). the drb1 frequencies were determined in the patients and controls. hla-drb1∗04 was negatively associated with uc. furthermore,hla-drb1∗13 was significantly associated with severity of the disease (p=0.01) among uc patients. this is the novel result that describes an association of hla-drb1∗13 with uc and also shows the protective role of hla-drb1∗04 against the disease in people of kerman. copyright © spring 2015,iran j allergy asthma immunol. all rights reserved.
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کلیدواژه
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HLA-DRB1; IBD; Iran; PCR-SSP; Ulcerative colitis
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آدرس
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physiology research center,institute of neuropharmacology,kerman universityof medical sciences,kerman,iran,department of immunology,school of medicine,mashhad university of medical sciences, ایران, mashhad university of medical sciences, ایران, inflammation and inflammatory diseases research center,school of medicine,mashhad university of medical sciences, ایران, physiology research center,institute of neuropharmacology,kerman universityof medical sciences, ایران, department of gastroenterology,afzalipour hospital,kerman university of medical sciences, ایران, mashhad university of medical sciences, ایران, kerman university of medical sciences, ایران, department of gastroenterology,afzalipour hospital,kerman university of medical sciences,kerman,iran,gastroenterology and hepatology research center,institute of basic and clinical physiology sciences,kerman university of medical sciences, ایران
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Authors
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