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Association of tumor necrosis factor alpha 308 G/A polymorphism with Asthma in Pakistani population
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نویسنده
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saba n. ,yusuf o. ,rehman s. ,munir s. ,bashir n. ,mansoor a. ,raja g.k.
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منبع
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iranian journal of allergy, asthma and immunology - 2015 - دوره : 14 - شماره : 3 - صفحه:287 -291
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چکیده
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Asthma is a chronic inflammatory and remodeling disorder of the airways,in which many cells,cellular elements,and cytokines play important roles. the role of tumor necrosis factor-α (tnf-α) in asthma is unclear in pakistani population. the aim of this study was to assess the relationship between tnf-α-308 polymorphism and asthma. polymorphism of tnf-α (g-308-a locus; rs 1800629) in 329 asthmatic patients and 151 healthy controls was evaluated. dna was prepared from blood samples of cases and controls. samples were genotyped for tnf-α 308 g/a polymorphism. there was no significant difference in the frequency of gg (or 1.049 with 95% ci 0.68-1.63) and ga (or 0.987 with 95% ci 0.64-1.53) genotypes of tnf-α-308. the aa genotype was absent in cases and only one aa genotype was observed in the controls. the genetic polymorphism of tnf-α does not seem to be associated with asthma in pakistani population. copyright © spring 2015,iran j allergy asthma immunol. all rights reserved.
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کلیدواژه
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Asthma; Pakistani population; TNF alpha 308
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آدرس
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institute of biomedical and genetic engineering,g-9/1,islamabad,pakistan,department of biochemistry,pirmehar ali shah arid agriculture university, Pakistan, allergy and asthma institute of pakistan, Pakistan, institute of biomedical and genetic engineering,g-9/1, Pakistan, institute of biomedical and genetic engineering,g-9/1, Pakistan, chest and medical specialist,medicsi, Pakistan, institute of biomedical and genetic engineering,g-9/1, Pakistan, department of biochemistry,pirmehar ali shah arid agriculture university, Pakistan
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Authors
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