Toxocara canis IgG seropositivity in patients with chronic urticaria

We aimed to investigate igg antibody levels specific to toxocara canis (t. canis),a parasite which subsists in dog's intestine,on serum samples obtained from patients with chronic urticaria (cu) to evaluate effective risk in cu etiopathogenesis. in this study,73 patients diagnosed with cu and 109 healthy individuals as control group,were included. various factors such as sex,age,education and income,daily hand washing habits,history of dog owning and soil eating were questioned in patient anamnesis. t. canis igg antibodies were detected using an enzyme linked immunosorbent assay (elisa) kit prepared with t. canis larval excretory-secretory antigens. positive results were confirmed with western blot (wb) wb test. we found t. canis igg positivity in 17.8% (n=13) of patients (n=73) with cu. but we did not observe any t. canis igg positivity in healthy controls (n=109). low molecular weight bands (24-35 kda) were observed in 11 samples in wb analyses while two of the samples were weakly positive. it is revealed that dog owning history increases t. canis seropositivity 12.9 times while insufficient daily hand washing habit (less than six times a day) increases seropositivity 20.7 times. our study showed that t. canis may trigger cu since we found 17.8% seropositivity in 73 patients with cu and none in 109 healthy individuals. moreover,various socio-demographic characteristics have been shown to affect t. canis seropositivity in patients with cu. copyright© summer 2015,iran j allergy asthma immunol. all rights reserved.