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Paraoxonase (PON1) 55 Polymorphism and Association with Systemic Lupus Erythematosus
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نویسنده
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Bahrehmand Fariborz ,Vaisi-Raygani Asad ,Ahmadi Reza ,Kiani Amir ,Rahimi Zohreh ,Tavilani Haidar ,Pourmotabbed Tayebeh
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منبع
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iranian journal of allergy, asthma and immunology - 2013 - دوره : 12 - شماره : 3 - صفحه:211 -219
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چکیده
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Paraoxonase-1 (pon1) is a serum hdl-bound enzyme that hydrolyzes a number of aromatic carboxylic acid esters including lipid peroxides, preventing ldl oxidation. systemic lupus erythematosus (sle) patients are at greater risk of oxidative stress, which is associated with abnormal plasma lipid metabolism. in this study, association of pon-55 polymorphism with serum arylesterase (are) activities, malondialdehyde (mda), neopterin, lipids and lipoproteins levels in sle patients and the development of hypertension was investigated. the present case–control study consisted of 109 sle patients with and without high blood pressure (bp) and 103 healthy controls from the population in the west of iran. pon-55 met
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کلیدواژه
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Arylesterase activity; Blood pressure; Lipid profile; Malondialdehyde; Paraoxonase 55genotype; Systemic lupus erythematosus
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آدرس
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kermanshah university of medical sciences, Molecular Diagnostic Research Center, ایران, kermanshah university of medical sciences, Molecular Diagnostic Research Center, ایران, kermanshah university of medical sciences, Molecular Diagnostic Research Center, ایران, shahid beheshti university of medical sciences, Department of Pharmacology and Toxicology, ایران, kermanshah university of medical sciences, Department of Clinical Biochemistry, ایران, hamadan university of medical sciences, Department of Clinical Biochemistry, ایران, University of Tennessee, Health Science Center, Department of Microbiology, Immunology and Biochemistry, USA
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Authors
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