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Immunogenicity Assessment of Brucella mellitensis HSP and TF Proteins by Immunized Rabbit Serum
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نویسنده
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Ghasemi Amir ,Salari Mohammad Hossein ,Zarnani Amir Hassan ,Pourmand Mohammad Reza ,Ahmadi Hojat ,Shirazi Mohamad Hassan ,Jeddi-Tehrani Mahmood
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منبع
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iranian journal of allergy, asthma and immunology - 2013 - دوره : 12 - شماره : 2 - صفحه:192 -194
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چکیده
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Bacteria of the genus brucella are facultative intracellular pathogens which have developed the capacity to survive and multiply in professional and nonprofessional phagocytes. due to drawbacks of live attenuated vaccines, much attention has been focused on screening brucella-protective antigens as subunit vaccine candidates. in order to screen immunogenic candidate antigens for the development of a brucella subunit vaccine, we cloned, expressed and purified heat shock protein (hsp) and trigger factor (tf) from brucella melitensis.
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کلیدواژه
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Brucella; Cloning; ELISA; Immunogenicity; Protein Expression; Purification
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آدرس
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tehran university of medical sciences tums, School of Public Health, Department of Pathobiology, ایران, tehran university of medical sciences tums, School of Public Health, Department of Pathobiology, ایران, Academic Center for Education, Culture and Research (ACECR), Avicenna Research Institute, Nanobiotechnology Research Center, ایران. tehran university of medical sciences tums, Immunology Research Center, ایران, tehran university of medical sciences tums, School of Public Health, Department of Pathobiology, ایران, Pasteur Institute of Iran, Department of Bacterial Vaccines and Antigen Production, ایران, tehran university of medical sciences tums, School of Public Health, Department of Pathobiology, ایران, Academic Center for Education, Culture and Research (ACECR), Avicenna Research Institute, Monoclonal Antibody Research Center, ایران
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Authors
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