Relationship Between Probiotic Consumption and Il-10 and Il-17 Secreted By Pbmcs in Overweight and Obese People

Epidemiological evidence has linked obesity to pro-inflammatory conditions such as cancer, asthma and autoimmune diseases. t lymphocytes, macrophages, and the proinflammatory cytokines produced by these cells play key roles in the immunological disturbances accompanying obesity. t lymphocytes exhibit pro-inflammatory or anti-inflammatory properties, depending on their subtypes. obesity is associated with state of chronic low-grade inflammation, as demonstrated by increased levels of acute-phase proteins and pro-inflammatory mediators in serum of obese individuals compared with lean subjects.2 in obesity, apart from the immune cells, adipose tissue contributes as a significant source of circulating serum interleukin(il)-6. in other words adipocytes secrete cytokines such as immune cells. moreover, il-6 is essential for the differentiation of naïve cd4 t cells into the t helper (th)17 subset and il-17 secretion.3 il-17, also referred to il-17a, is a pro-inflammatory cytokine which has a pivotal role in autoimmune diseases.