Autoantigens and Autoantibodies in Multiple Sclerosis

Multiple sclerosis (ms) is an autoimmune disease characterized by recurrent episodes of demyelination and axonal lesion mediated by cd4+ t cells with a proinflammatory t helper (th)1 and th17 phenotypes, macrophages, and soluble inflammatory mediators. the overactive pro-inflammatory th1 cells and clonal expansion of b cells initiate an inflammatory cascade with several cellular and molecular immune components participating in ms pathogenic mechanisms. in this scenario, autoantibodies and autoantigens have a significant role in immunopathogenesis, diagnosis and therapeutic targets of ms. in this review, we try to introduce the autoantigens and autoantibodies and explain their roles in pathogenesis of ms.