|
|
|
|
investigating novel biomarkers in endometrial cancer – a study on rt-qpcr and immunohistochemistry
|
|
|
|
|
|
|
|
نویسنده
|
li rong ,yan ying ,liu fei ,gao xiaoyu ,fu xianling ,hu luona ,li yanhong
|
|
منبع
|
iranian journal of allergy, asthma and immunology - 2025 - دوره : 24 - شماره : 6 - صفحه:808 -817
|
|
چکیده
|
This study aimed to investigate the expression patterns of hoxb9, dlx5, ngr1, and gata6 in endometrial cancer tissues compared to adjacent non-cancerous tissues. using rt-qpcr and immunohistochemistry, the researchers found significant upregulation of hoxb9, dlx5, and ngr1, and downregulation of gata6 in endometrial cancer samples. the biomarker expression levels correlated with clinicopathological features, and survival analysis revealed that high expression of hoxb9, dlx5, and ngr1 was associated with poorer prognosis, while high gata6 expression indicated better outcomes. these findings suggest that these biomarkers may play crucial roles in endometrial cancer development and progression, highlighting their potential as diagnostic, prognostic, and therapeutic targets.
|
|
کلیدواژه
|
biomarkers ,dlx5 ,endometrial cancer ,gata6 ,hoxb9 ,immunohistochemistry ,ngr1 ,prognosis ,qpcr ,rt
|
|
آدرس
|
air force medical university, tangdu hospital, department of obstetrics and gynecology, china, air force medical university, tangdu hospital, department of obstetrics and gynecology, china, air force medical university, tangdu hospital, department of obstetrics and gynecology, china, air force medical university, tangdu hospital, department of obstetrics and gynecology, china, air force medical university, tangdu hospital, department of obstetrics and gynecology, china, air force medical university, tangdu hospital, department of obstetrics and gynecology, china, air force medical university, tangdu hospital, department of obstetrics and gynecology, china
|
|
پست الکترونیکی
|
yanhongli794@gmail.com
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|