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assessment of the anti-cancer effects of camel milk exosomes (cmexos) on murine colorectal cancer cell line (ct-26)
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نویسنده
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karbasi samira ,erfanian nafiseh ,dehghan hamideh ,zarban asghar ,namaei mahammad hasan ,hanafi-bojd mohammad yahya ,nasseri saeed
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منبع
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iranian journal of allergy, asthma and immunology - 2024 - دوره : 23 - شماره : 3 - صفحه:321 -329
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چکیده
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Today, camel milk consumption in the middle east is trendy because it is believed that it reduces the risk of cancer. recently, studies have discovered that most of milk's beneficial effects are because of its nanoparticles, especially exosomes. the objective of the present research was to investigate the anti-cancer effects of camel milk exosomes (cmexos) in the murine colorectal cancer cell line (ct-26).our findings verified the existence of exosomes measuring approximately 114.1±3.4 nm in diameter. through mtt and migration assays, we established that cmexos exhibit dose-dependent anti-proliferative and anti-migration effects on the ct-26 cell line. furthermore, our study showed that treatment with cmexos led to a reduction in tnf-α and il-6 gene expression in ct-26 cells.while additional in vivo studies are required, our data demonstrate that cmexos have anti-proliferative and anti-migration effects on ct-26, possibly by influencing crucial genes within the inflammation pathway.
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کلیدواژه
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camel milk ,colorectal cancer ,exosomes ,il-6
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آدرس
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birjand university of medical sciences, cardiovascular diseases research center, iran, birjand university of medical sciences, student research committee, faculty of medicine, department of molecular medicine, iran, birjand university of medical sciences, student research committee, faculty of medicine, iran, birjand university of medical sciences, cardiovascular diseases research center, faculty of medicine, department of clinical biochemistry, iran, birjand university of medical sciences, infectious diseases research center, iran, birjand university of medical sciences, cellular and molecular research center, iran, birjand university of medical sciences, cellular and molecular research center, iran
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پست الکترونیکی
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saeed.nasseri922@gmail.com
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Authors
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