a case of insidious onset of kimura disease-associated immunoglobulin a nephropathy without eosinophil infiltration in the renal tissue

Kimura disease (kd), also known as eosinophilic lymphogranuloma, is a rare chronic inflammatory or allergic disease. it can present with immune-related diseases such as nephrotic syndrome, asthma, and ankylosing spondylitis. in this study, we report a case of kd combined with immunoglobulin a nephropathy that first presented as a mass in the inguinal region, followed by recurrent renal involvement. previous reports suggested that renal involvement caused by kd was due to direct infiltration of eosinophils; however, in this case, no eosinophil infiltration was found in the renal tissue after renal biopsy. this observation reminds us to approach the case from an immune-related molecular perspective to investigate the exact cause of renal damage due to kd.