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regulatory effects of long non-coding rnas on th17/treg differentiation and imbalance
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نویسنده
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dabbaghipour reza ,ahmadi elham ,entezam mona ,rahbar farzam omid ,baghbanzadeh amir ,saber sichani ali ,jalilzadeh nazila ,jafarlou mahdi ,baradaran behzad
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منبع
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iranian journal of allergy, asthma and immunology - 2023 - دوره : 22 - شماره : 6 - صفحه:512 -526
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چکیده
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Scientific research over the past decades has proven the pivotal role of long non-coding rnas (lncrnas) in regulating gene expression. the immune responses are controlled through the interaction of pro-inflammatory (predominance of t helper 17 cells (th17)) and anti-inflammatory cytokines excretion (predominance of regulatory t cells (treg)). recent studies have marked the impact of many diverse lncrnas on treg/th17 imbalances. moreover, some of the roots and causes of human diseases can be associated with the alterations in the th17/treg ratio. in this review study, we overviewed the association between lncrnas and th17/treg, with the potential of providing novel prognostic and diagnostic biomarkers and promising therapeutic targets in various diseases, particularly cancer.
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کلیدواژه
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long non-coding rna ,regulatory t cells ,t helper 17 cells
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آدرس
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shiraz university of medical sciences, department of medical genetics, iran. tabriz university of medical sciences, immunology research center, iran, tabriz university of medical sciences, immunology research center, iran, shiraz university of medical sciences, department of medical genetics, iran, tabriz university of medical sciences, immunology research center, iran, tabriz university of medical sciences, immunology research center, iran, texas a&m university, college station, department of biology, usa, tabriz university of medical sciences, immunology research center, iran, tabriz university of medical sciences, immunology research center, iran, tabriz university of medical sciences, immunology research center, faculty of medicine, department of immunology, iran
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پست الکترونیکی
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behzad_im@yahoo.com
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Authors
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