study effect of vitamin d on the immunopathology responses of the bronchi in murine model of asthma

Allergic asthma is a complicated respiratory problem characterized by airway inflammation,airway hyperresponsiveness (ahr), breathlessness, mucus hyper-secretion, and goblet cellhyperplasia. asthma is controlled by genetic and environmental factors. allergy is the main triggerof asthma and is mediated by th2 cytokines along with ige production. vitamin d (vit d) is themain supplementary factor for the immune system. in the present study, we investigated the effectof vit d on the exacerbation of allergic asthma.a murine model of allergic asthma was induced by ovalbumin (ova) in four of five groups ofstudied female balb/c mice (each group, n=20). one group was considered as control. ofova-induced mice, two groups received vit d via oral (10,000 iu/kg diet) or intranasal(inhalation) forms (30 min on days 25, 27, and 29), and the third group received budesonide. atleast, ahr, the levels of il-4, il-5, il-13, and inf-γ in bronchoalveolar lavage fluid (balf),serum ige and histamine, il-25 and il-33 gene expression, as well as histopathology study of thelung were done.the penh values, type2 cytokines in balf (in both protein and molecular levels), total igeand histamine, perivascular and peribronchial inflammation, goblet cell hyperplasia, and mucushypersecretion decreased significantly in both oral and intranasal vit d-treated asthmatic micegroups, especially on day 38 of orally treated mice.here, we found vit d as a promising agent in control of allergic asthma with a remarkableability to decrease the severity of inflammation. therefore, vit d sufficiency is highlyrecommended in asthmatic patients.