Recurrent Infections and Cows-milk Hypersensitivity in a 2-Year-Old Girl with Hyper Immunoglobulin E Syndrome

The hyperimmunoglobulin e syndrome is a rare complex primary immunodeficiency characterized by high serum ige levels, eczema, and recurrent infections. we present a case of 2-years-old girl with eczema and repeated bacterial skin and lung infections since the period of infancy. the patient also had eosinophilia, high serum levels of ige, and cows-milk hypersensitivity. we describe the case, in order to illustrate the difficulty of establishing the diagnosis hyper-immunoglobulin e syndrome in a toddler.