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IL7R and RAG1/2 Genes Mutations/Polymorphisms in Patients SCID
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نویسنده
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Safaei Sepideh ,Pourpak Zahra ,Moin Mostafa ,Houshmand Massoud
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منبع
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iranian journal of allergy, asthma and immunology - 2011 - دوره : 10 - شماره : 2 - صفحه:129 -132
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چکیده
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Scid disorder is major failure of the immune system, usually genetic. the aim of this study was on mutations detection of rag1, rag2, and il7rg genes in scid cases. mutation detection was performed by pcr sequencing. our results indicated that 13 mutations were found through cases which include 4 mutations in il7r gene (t661i, i138v, t56a, c57w), 7 mutations in rag1 (w896x, w204r, m324v, t731i, m1006v, k820r, and r249h), and 2 mutations in rag2 gene (r229w, δt251).
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کلیدواژه
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IL7R ,RAG1; RAG2; Severe Combined Immunodeficiency Disorder
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آدرس
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tehran university of medical sciences tums, Children’s Medical Center, Department of Immunology, Asthma & Allergy Research Institute, ایران, tehran university of medical sciences tums, Children’s Medical Center, Department of Immunology, Asthma & Allergy Research Institute, ایران, tehran university of medical sciences tums, Children’s Medical Center, Immunology, Asthma & Allergy Research Institute, ایران, National Institute for Genetic Engineering and Biotechnology, ایران
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پست الکترونیکی
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massoudh@nigeb.ac.ir
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Authors
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