the study of relationship between serum levels of soluble fms-like tyrosine kinase-1 and soluble fibrinogen-like protein 2 with delayed graft function after kidney transplantation

Delayed graft function (dgf) is a transplant complication which means a need to dialysis throughout the first week after transplantation. this study aimed to ascertain the relationship between the two immunomodulatory factors of soluble fms-like tyrosine kinase-1 (sflt-1) and soluble fibrinogen-like protein 2 (sfgl-2) with dgf after transplantation. this case-control study was done in 2 groups of 58 kidney transplant patients with and without dgf. the control group included the patients who didn’t show dgf symptoms. then, serum levels of sflt-1and sfgl-2 in all blood samples were measured by elisa. serum sflt-1 and sfgl-2 levels were significantly higher in the dgf group compared to those in the control group (p≤0.001). sflt-1 and sfgl-2 serum levels significantly affect dgf (p<0.001) in such a way that they may be diagnostic factors of dgf. this study showed a significant relationship between sflt-1 as well as sfgl-2 and dgf. therefore, plasma levels of sflt-1 and sfgl-2 may be used as diagnostic tools to determine the risk of dgf.