|
|
|
|
radio-protective effect of hydrogen rich water combined with amifostine in mice
|
|
|
|
|
|
|
|
نویسنده
|
qin x. ,qin x. ,qin x. ,yin j. ,yin j. ,li j. ,li j. ,an q. ,an q. ,wen j. ,wen j. ,niu q.
|
|
منبع
|
international journal of radiation research - 2016 - دوره : 14 - شماره : 2 - صفحه:113 -118
|
|
چکیده
|
Background: hydrogen has been demonstrated can selectively reduce the hydroxyl, which is the main cause of ionizing radiationinduced damage. amifostine (am) is the only radioprotective drug approved by the u.s. food and drug administration for use in radiotherapy. the purpose of the present study was to investigate the combined radioprotective effect of hydrogen rich water (hrw) and am. materials and methods: male icr mice were treated intragastrically with hrw or/and intraperitoneally with am 30 minutes prior to 9.0 gy whole body irradiation from a 60co source (dose rate 0.96gy/min). then the survival rate for 30 days, the hematological parameters, the clinical chemistry parameters and the bone marrow nucleated cells were examined. results: we found that the mice treated with hrw and am before irradiation could increase the 30day survival rate and improve the body weight better than the hrw or am treatment alone group and irradiation alone group. hematological test and clinical chemistry assays also showed the same results that hrw combined am could better improve the recovery of hemopoietic system and alleviate the detrimental effects of radiation. conclusion: the results indicate that the combined application of hrw and am may be a better method for radiation therapy.
|
|
کلیدواژه
|
ionizing radiation ,radioprotection ,hydrogen rich water ,amifostine ,mice
|
|
آدرس
|
shanxi medical university, school of public health, department of occupational health, china. china institute for radiation protection, department of radiation medicine and environment medicine, china. shanxi key laboratory of drug toxicology and drug for radiation injury, china, shanxi medical university, school of public health, department of occupational health, china. china institute for radiation protection, department of radiation medicine and environment medicine, china. shanxi key laboratory of drug toxicology and drug for radiation injury, china, shanxi medical university, school of public health, department of occupational health, china. china institute for radiation protection, department of radiation medicine and environment medicine, china. shanxi key laboratory of drug toxicology and drug for radiation injury, china, china institute for radiation protection, department of radiation medicine and environment medicine, china. shanxi key laboratory of drug toxicology and drug for radiation injury, china, china institute for radiation protection, department of radiation medicine and environment medicine, china. shanxi key laboratory of drug toxicology and drug for radiation injury, china, china institute for radiation protection, department of radiation medicine and environment medicine, china. shanxi key laboratory of drug toxicology and drug for radiation injury, china, china institute for radiation protection, department of radiation medicine and environment medicine, china. shanxi key laboratory of drug toxicology and drug for radiation injury, china, china institute for radiation protection, department of radiation medicine and environment medicine, china. shanxi key laboratory of drug toxicology and drug for radiation injury, china, china institute for radiation protection, department of radiation medicine and environment medicine, china. shanxi key laboratory of drug toxicology and drug for radiation injury, china, china institute for radiation protection, department of radiation medicine and environment medicine, china. shanxi key laboratory of drug toxicology and drug for radiation injury, china, china institute for radiation protection, department of radiation medicine and environment medicine, china. shanxi key laboratory of drug toxicology and drug for radiation injury, china, shanxi medical university, school of public health, department of occupational health, china
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|