Nano selenium-lovastatin mixture modulate inflammatory cascade in arthritic irradiated model

Background:the development of nanotechnology has been a boon to mankind as its significance paved the way for several applications in therapeutics. this study was to evaluate the anti-arthritic capability of nano selenium-lovastatin mixture (lov-se) against inflammatory cascade in arthritic irradiated rats. materials and methods: animal model of arthritis was organized by subcutaneous injection of complete freund’s adjuvant; cfa. rats were exposed to γ-radiation (2gy every 3 days up to total dose of 8 gy). lov-se (1ml ≈ 20 mg kg^−1 day^−1lov and 0.1 mg kg^−1 day^−1se) was administrated by daily oral injection. the antioxidant parameters (heart glutathione peroxides; gsh-px, catalase; cat, superoxide dismutase; sod, xanthine dehydrogenase; xdh, reduced glutathione; gsh and blood selenium; se), oxidant markers (heart xanthine oxidase; xo, nitric oxide; no, protein carbonyls and thiobarbituric acid reactive substances; tbars) and the inflammatory molecules (serum tumor necrosis factor-alpha tnf-α, c-reactive protein; crp and rheumatoid factor; rf) were determined. results: the arthritic and arthritic irradiated rats were displayed augment oxidative stress, inflammatory cascade and impaired antioxidant status compared to control. conclusion: the data revealed that lov-se administration ameliorate oxidative, antioxidants parameters as well as inflammatory factors. the prolonged administration of lov-se mixture in appropriate concentration could exert a considerable systemic anti-inflammatory action through adjustment of red-ox tone and the integration of xdh/xo ratio.