Value of dynamic contrast-enhanced magnetic resonance imaging quantitative parameters in evaluating the efficacy of neoadjuvant chemoradiotherapy for cervical cancer

Background: this study focused on evaluating the effectiveness of dynamic contrast-enhanced magnetic resonance imaging (dce-mri) in patients with cervical cancer (cc) undergoing neoadjuvant chemotherapy and radiation therapy. materials and methods: a total of 58 cc patients were included, undergoing examination through dce-mri scans. subsequently, all cases were divided into two groups: the chemotherapy-effective group (32 cases) including complete response (cr) and partial response (pr), and the chemotherapy-ineffective group (26 cases) including stable disease (sd) and disease progression (pd). results: after treatment, the average maximum diameter of tumors in the chemotherapy and radiation therapy failure group was 4.38 ± 1.23 cm, drastically larger than the 2.51±0.64 cm in the chemotherapy and radiation therapy response group (p < 0.05). before treatment, the ktrans of the chemotherapy and radiation therapy response group was superior to that of the failure group, while ve was inferior to the latter (p < 0.05). after treatment, the ktrans of the chemotherapy and radiation therapy response group decreased, showing a more drastic reduction compared to the failure group (p < 0.05). the ktrans of the chemotherapy and radiation therapy response group was drastically inferior to that of the failure group, with statistical significance (p<0.05). the δktrans% in the chemotherapy and radiation therapy response group was negative, inferior to pre-treatment values. in contrast, the δktrans% in the chemotherapy and radiation therapy failure group was positive, superior to pre-treatment values (p < 0.05). conclusion: dce-mri demonstrates excellent scanning performance for cc, accurately monitoring the blood flow signals of cc tumors. ktrans, ve, and δktrans have high predictive value in neoadjuvant chemotherapy and radiation therapy.