Diffusion characteristics of diffusion-weighted imaging in children with hippocampus injury during complex acute febrile seizure: a prospective observational study

Background: to explore the diffusion characteristics of the hippocampus injury (hi) in children during the complex acute febrile seizure (cafs) through multiple b value (1000-2000 s/mm2) of diffusion-weighted imaging (dwi). materials and methods: this prospective observational study enrolled children with hi during cafs, and nasopharyngeal and sinus disease (nsd). the multiple b value from dwi of the hippocampus were scanned. results: a total of 41 children were included, with 21 of them had hi during cafs, while the other 20 children were nsd. there was significant difference in apparent diffusion coefficient (adc) values of the left and right hippocampus between children with hi during cafs and nsd (r < 0.05). the corresponding adc graphs were relatively clear at b = 1000 s/mm2 and 1200 s/mm2. conclusion: hippocampal dwi scans at b = 1000 s/mm2 and 1200 s/mm2 might be recommended clinical b value point for diffusion characterization of hi.