Hepatoprotective effects of the mixed decoction of Inula cappa and Serissa japonica in acute liver injury mouse model

Background: to explore the effectiveness of the mixed decoction of inula cappa and serissa japonica (is) on acute liver injury model. materials and methods: sixty carbon tetrachloride (ccl4)-induced mice models were divided into bifendate group (0.2 g/kg) and is (2, 1and 0.5 g/kg) groups, model group, and control group randomly. liver function biomarkers aspartate aminotransferase (ast), alanine amiotransferase (alt), and oxidative stress biomarkers superoxide dismutase (sod), malonic dialdehyde (mda) were measured in each group. hematoxylin and eosin (he) staining was used to detect the liver tissues. results: the necrosis degree and scope, and the structural damage of hepatocyte were significantly ameliorated in the bifendate, is (2 g/kg) and is (1 g/kg), compare to model group. is and bifendate could significantly inhibit the liver index, reduce liver function biomarkers levels and the content of mda in the liver of acute liver injury mice, and improve the activity of sod. the serum level of ast was 147.162 (control), 736.023 (model), 370.285 (bifendate), 325.589 (high-dose is), 407.205 (middle-dose is), and 438.631 u/l (low-dose is) while the level of alt was 44.804 (control), 474.825 (model), 156.812 (bifendate), 157.02 (high-dose is), 217.399 (middle-dose is), and 255.649 u/l (low-dose is). the content of mda increased in model and treatment groups compared to control, while the activity of sod was 69.362 (control), 53.208 (model), 64.77 (bifendate), 73.389 (high-dose is), 65.173 (middle-dose is), and 61.755 (low-dose is). compared to the model group, high-dose is group exerted significant hepatoprotective effect (p<0.05). conclusion: the mixed decoction of inula cappa and serissa japonica was able to protect acute liver injury.