Platelet-rich plasma alleviates skin photoaging and oxidative stress in rats by regulating autophagy and inhibiting the NLRP 3 inflammasome pathway

Background: background: ultraviolet radiation is the main cause of photoaging, which can induce oxidative stress and cellular senescence in the skin. it has been demonstrated that platelet-rich plasma (prp) can significantly improve skin photoaging. however, the mechanism by which prp improves photoaging remains unclear. materials and methods: in this study, uva-induced sd rats were used as a skin photoaging model and administered with prp treatment, aiming to elucidate the potential mechanism of its protection against photoaging. results: they showed that prp injection on the back of rats improved skin photoaging, oxidative stress, and inflammation, and inhibited skin cell apoptosis. in addition, rpr activated autophagy to inhibit nod-like receptor thermal protein domain associated protein 3 (nlrp3) inflammasome signaling pathway-related proteins. conclusion: our experimental results suggest that prp plays an anti-uva photoaging role by inhibiting autophagy and nlrp3 signaling pathways. our study is the first to suggest that prp anti-skin photoaging is associated with autophagy and nlrp3, providing a potential therapeutic approach for skin photoaging.